CD56 and Tim-3 molecule expression in different monocyte subsets in physiological pregnancy
نویسندگان
چکیده
Monocytes play an important role in the systemic immune defense against pathogens and maintaining physiological pregnancy. During pregnancy peripheral monocytes migrate into decidua form pool of decidual macrophages which participate formation development placental tissues. The population blood is phenotypically functionally heterogeneous. In humans, there are different monocyte subsets depending on expression CD14 CD16. CD56-positive found healthy women. Their number positively correlated with body mass index, fat. Tim-3 (T cell Ig mucin domain-containing protein 3) observed during It known that functions effectively change at to tolerance maternal-fetal interface pathogens. However, phenotype shift remain poorly understood. Therefore, aim study was evaluate CD56 expressions human Peripheral mononuclear cells were isolated from pregnant women (gestational age 29 weeks (28-31) by density gradient centrifugation analyzed flow cytometry. non-pregnant fertile (in follicular phase menstrual cycle) aged 21-29 years studied as control. Pregnant had a lower percentage classical hi /CD16 - comparison non-pregnant. percentages intermediate (CD14 + ) non-classical low did not change. molecule all higher CD16 than double-positive increased numbers Thus, changed
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ژورنال
عنوان ژورنال: ??????????? ???????????
سال: 2023
ISSN: ['2409-5788']
DOI: https://doi.org/10.15789/1563-0625-cat-2792